Post Doctoral Fellow-MSH-32086-002

Department: Pharmacological Sciences

Physical work location: 1428 Madison Ave, NY, NY 10029

Name PI or Supervisor: Mone Zaidi, (212)241-8798, mone.zaidi@mssm.edu

Web link to Department: https://icahn.mssm.edu/about/departments/pharmacological-sciences

Administrative Contact: Susan Babunovic, 212-241-8797, susan.babunovic@mssm.edu

Conduct research that integrates experimental immunology with computational analyses of omics data. The position requires designing, executing, and analyzing both wet lab assays and computational pipelines, with the goal of advancing translational approaches to immunology and transplantation biology. The fellow will also prepare manuscripts, present findings at conferences, and collaborate closely with clinicians and scientists.

Specific Research Project: The fellow will lead a funded project focused on developing and applying a novel dynamic fluorescent biosensor (FJ375) to evaluate redox homeostasis in T lymphocytes as a biomarker for acute cellular rejection (ACR) in heart transplant recipients.

The project will:

• Characterize the redox metabolic profile of T cell subsets (effector T cells and regulatory T cells) in transplant recipients.
• Assess the diagnostic performance of FJ375 for detecting acute cellular rejection, compared with current standards (donor-derived cell-free DNA and gene expression profiling).
• Determine the prognostic capacity of redox signatures for predicting persistent rejection.
• Explore the influence of immunosuppressive therapy on T cell redox balance through ex vivo assays.
• Integrate clinical, immunological, and computational analyses to identify molecular correlates of immune tolerance and risk of rejection.

This project involves both laboratory experiments (flow cytometry, cell culture, redox profiling) and computational modeling of clinical and omics data. The ultimate goal is to develop new biomarkers that improve rejection surveillance and guide personalized immunosuppression strategies in cardiac transplantation.

Experience Required:

• PhD, MD, or MD/PhD in Immunology, Computational Biology, Bioinformatics, Molecular Biology, or a related field.
• Demonstrated expertise in wet lab immunology techniques (e.g., flow cytometry, cell culture, molecular assays).
• Experience with computational methods and programming (R, Python, or similar) applied to biological datasets.
• Strong initiative, independence, and ability to integrate clinical and basic science questions.
• Excellent communication and collaborative skills.
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Goals/Outcomes of the Research Project: The ultimate goal is to develop new biomarkers that improve rejection surveillance and guide personalized immunosuppression strategies in cardiac transplantation.

 

Compensation Statement

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $74,692.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), IEK - Institute for Translational Medicine and Pharmacology - ISM, Icahn School of Medicine