Senior Hardware Engineer, Nanofabrication and MEMS Development

Cambridge$108k–$176kPosted Aug 5, 2026

About Tilde (FL110)

Tilde Bio, Inc. (FL110) is building a next-generation biological sensing platform at the intersection of synthetic biology, protein engineering, nanopore biophysics, electrophysiology, signal processing, and machine learning. Our goal is to create programmable biological measurement systems capable of extracting rich molecular information from single-molecule interactions.

We believe nanopores generate a high-dimensional measurement of molecular identity and behavior that remains largely untapped. Unlocking that information requires new computational approaches — ones that don't yet exist — built by people who are comfortable working at the edge of what's known. At Tilde, you will work alongside scientists and engineers from diverse disciplines to help define how a new generation of biological sensing systems extract meaning from the physical world.

Tilde is backed by Flagship Pioneering, which brings the long-term vision and resources needed to build platforms that don't fit neatly into existing categories.

Position Summary

We are seeking a highly skilled and innovative Senior Nanofabrication Engineer to drive the development of MEMS-based sensor architectures and micro/nanoscale structures that are core to our next-generation proteomics platform. This individual will play a critical role in designing, fabricating, and optimizing micro- and nanoscale devices, translating novel concepts into robust, manufacturable processes.

The ideal candidate has deep hands-on experience in MEMS fabrication, cleanroom process development, and microfabrication techniques including lithography, etching, deposition, and thin-film processing. Because our sensors operate at the interface of silicon and biology, experience integrating microfabricated devices with fluidic, chemical, or biological systems is highly valued. This role requires close collaboration with electrical, mechanical, materials, and bioengineering teams to ensure seamless integration of MEMS sensors into larger instrument systems. This is an on-site position requiring regular cleanroom and lab work.

Key Responsibilities

Lead the design, fabrication, and optimization of MEMS-based sensor components and microscale structures, from concept through manufacturable process.
Develop and optimize cleanroom process flows including photolithography, thin-film deposition (PVD/CVD/ALD), dry and wet etching, and wafer bonding.
Design masks and layouts, and characterize micro- and nanoscale structures using metrology tools such as SEM, profilometry, ellipsometry, and optical microscopy.
Perform failure analysis and root-cause investigations to improve yield and device performance.
Collaborate with electrical, systems, and bioengineering teams to integrate MEMS sensors with PCB, packaging, and fluidic/bio-interface solutions.
Support process transfer to external foundries or manufacturing partners, and maintain thorough documentation of processes, results, and design revisions.
Contribute to intellectual property development and technical strategy, and stay current with advancements in MEMS fabrication, materials science, and nanoscale device engineering.

Basic Qualifications

B.S., M.S., or Ph.D. in Electrical Engineering, Materials Science, Mechanical Engineering, Applied Physics, or a related field.
5+ years of hands-on experience in MEMS fabrication or micro/nanofabrication in industry or advanced research environments.
Demonstrated expertise in cleanroom processes including photolithography, thin-film deposition, and etching techniques (RIE/DRIE preferred).
Experience designing microstructures and mask layouts using CAD tools (e.g., L-Edit, KLayout, or similar).
Strong understanding of MEMS device physics and materials selection.
Experience with wafer-level processing and packaging considerations.
Hands-on experience with microfabrication characterization and metrology tools.
Strong problem-solving skills and the ability to iterate quickly in a fast-paced R&D environment.
Excellent written and verbal communication skills.

Nice-to-Haves

Experience developing MEMS-based sensing devices (mechanical, optical, electrical, or fluidic).
Familiarity with microfluidics or bio-integrated MEMS devices.
Experience with wafer bonding, surface functionalization, or nanostructure fabrication.
Prior experience working with external semiconductor foundries.
Experience in early-stage or startup environments.

About Flagship Pioneering

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies.

Flagship Pioneering and its ecosystem companies are committed to equal employment opportunity for all employees and applicants. We do not discriminate on the basis of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, gender identity or expression, disability, pregnancy, veteran status, genetic information, or any other characteristic protected by applicable law.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.

The salary range for this role is $108,000 - $176,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL110 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL110's good faith estimate as of the date of publication and may be modified in the future.