Scientist Nucleic Acids Computational Biology

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. BMS Launches to Advance New Frontiers of Science with the Next Generation of Innovative RNA Medicines! BMS is committed to enhancing global health by unleashing the full potential of RNA medicines to treat human disease in ways that were not previously possible. To achieve this vision, BMS is developing a first-in-kind RNA platform that integrates both established and emerging technologies and delivery mechanisms, excluding RNAi. The platform is engineered to extend the durability and half-life of BMS’s novel RNA therapeutics and to broaden their delivery to a wider range of cell types and tissues. As BMS’s RNA platform grows, it will continue to invest in expanding its platform capabilities and underlying technologies. Leveraging state-of-the-art RNA and novel delivery technologies, Orbital plans to build an expansive portfolio targeting a broad spectrum of human diseases, with initial focus areas including vaccines, immunomodulation, protein replacement, and regenerative medicine. JOB SUMMARY We are seeking a highly motivated and innovative scientist to drive advances at the interface of RNA biology, computational modeling, and machine learning. In this role, you will design and implement cutting-edge computational approaches to uncover RNA structure–function relationships and to support discovery and development programs across the organization. You will work with complex datasets and build computational tools that provide high-throughput, data-driven insights to accelerate next-generation mRNA medicines. The ideal candidate has a strong foundation in RNA biology, is proficient with RNA secondary structure analysis tools, and has hands-on programming experience in languages such as Python or R. You will work extensively in cloud-based, high-performance computing environments and apply modern software engineering practices to deliver robust, scalable, and well-documented computational solutions. This is a highly collaborative role, requiring close partnership with both wet-lab and dry-lab teams. You will manage multiple dynamic projects, help shape scientific strategy, and clearly communicate findings to stakeholders. A strong track record of impactful research—demonstrated by publications or patent contributions—is strongly preferred. If you excel in a fast-paced, interdisciplinary environment and are excited to push the boundaries of computational RNA science, we would love to hear from you. RESPONSIBILITIES * Build and implement custom mRNA optimization strategies to fine tune expression, stability, and immunogenicity, and function of the RNA payload. * Innovate on mRNA designs by utilizing scientific literature to implement novel design principles. * Collaborate within the RNA sciences team to generate and analyze NGS data from RNA structure probing and other RNA biology-directed experiments such as SHAPE-MaP, DMS-MaP, ribosome profiling, RIP-seq etc. * Lead cross‑functional collaboration with experimental biologists, molecular biologists, and therapeutic project teams to design studies, set experimental...