Clinical Scientist / Medical Director

Privacy PolicyJob OpeningsClinical Research Scientist / Medical DirectorLittle Chesterford, Cambridgeshire (Hybrid)Clinical Scientist / Medical Director   Chesterford Research Park – Cambridge Full Time Permanent Hybrid and on-site working – Flexible on presence On Site Parking Full benefits package   Never losing sight of our purposeMestag Therapeutics is a clinical-stage biotechnology company pioneering the discovery and development of antibody therapeutics targeting cancer and inflammatory disease. Our science is rooted in fibroblast immunology, leveraging cutting-edge biological and translational insights to uncover novel pathways that drive immune modulation in disease.  Mestag is backed by committed leading global investors, has world-class founders and a highly experienced leadership team.   We are now building a clinically focused, scientifically rigorous team to advance our pipeline through early and late-stage development. There has never been a better time to join us!  #Mestag   Scope of role We are seeking an experienced Clinical Scientist/Medical Director to provide clinical leadership for MST-0312, our lead oncology asset currently in Phase 1 development in solid tumours. Reporting to our CMO, this individual will act as the clinical lead for the programme, providing day-to-day medical and scientific oversight of the ongoing study, contributing to development strategy, and representing Mestag externally with investigators, key opinion leaders, and regulatory authorities. This is a hands-on clinical leadership role suited to someone who has previously taken full ownership of an oncology clinical programme, from protocol concept through to Clinical Study Report and who is comfortable operating in a small, fast-moving biotech environment. The role provides the opportunity to lead clinical strategy & execution for an active, clinical-stage oncology programme at a critical stage of development.     Key Responsibilities Serve as clinical lead for the MST-0312 programme, providing scientific and medical direction for the ongoing Phase 1 solid tumour study. Represent the clinical science function on the project team and subteam(s). Partner with the CMO to shape overall clinical development strategy for MST-0312, including evaluation/monitoring of the development & commercial landscape in which the programme is operating. Partner with the leadership team & project leader on development of target product profiles for the molecule in the indications selected. Provide clinical oversight of sponsored trials, including protocol interpretation, safety review, and eligibility/data queries in conjunction with the CRO medical monitor and safety team. Lead or significantly contribute to the clinical sections of regulatory submissions, including INDs/CTAs, briefing documents, and responses to regulatory authority queries. Author or oversee authorship of pre-IND (or equivalent pre-submission) briefing materials for interactions with major regulatory authorities Lead protocol, investigator brochure, DSUR & CSR development, partner with clinical operations lead on informed consent documents and study plans. Build and maintain relationships with investigators, clinical sites, and key opinion leaders in relevant oncology indications to support trial execution, scientific credibility, and future development planning. Represent Mestag at scientific conferences, advisory boards, and investigator meetings. Collaborate cross-functionally with clinical operations, biostatistics, regulatory affairs, pharmacovigilance, and translational/biomarker teams. Support data interpretation, abstract/manuscript development, and presentation of clinical results.   Qualifications and Experience Required. Must Have:   For the Medical Director: Hold a Medical Degree such as (MBBS, MBChB, MD or equivalent) with experience as outlined below For the Clinical Scientist : A bachelor’s degree or higher with experience as outlined below Direct experience...