Senior People Operations Manager
San Carlos, CAPosted Jun 16, 2026
Senior People Operations Manager LocationSan CarlosEmployment TypeFull timeDepartmentPeople & CultureCompensation$160K – $200K • Offers EquityThe hiring pay range for this position is based on skills, education, and experience relevant to the role. New hires are typically hired into the low to midpoint of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Pay ranges are adjusted based on cost of labor in each respective geographical market. Your recruiter can share more about the specific pay range for your location during the hiring process.Benefits include medical, vision, and dental insurance, group and supplemental life insurance, 401k retirement plan, responsible paid time off, parental leave, and more. Other components of total compensation include a competitive options grant at the time of hire (with potential for additional grants).At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome – one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.We are looking for a self-directed Senior People Operations Manager to own the infrastructure that makes our people experience work. This is an exciting opportunity for someone who geeks out on process efficiency, data integrity, and building people team infrastructure. This person will be the sole HR Operations owner on the team, which means they’ll have real scope, real autonomy, and real impact. You won't be waiting for someone to tell you what to do. You'll assess what's broken, propose a solution, and execute with appropriate partnership from HR leadership and cross-functional teams. The ideal candidate is equally comfortable pulling compensation benchmarking data, configuring an HRIS workflow, and presenting a process improvement recommendation to leadership. You move fast, simplify by default, and treat every operational touchpoint as an opportunity to make the employee experience better.Responsibilities• Serve as the internal owner of all HR/Talent systems and vendor relationships, including HR Information System (HRIS, Application Tracking System (ATS), Performance Management, leave management, etc.• Lead the evaluation, implementation, and optimization of HR technology, from configuration to adoption• Ensure data integrity across all people systems and serve as the connective tissue between HR, Finance, IT, and Legal• Build and maintain integrations and automations that reduce manual work and improve data reliability• Proactively identify and pilot AI tools and capabilities that can improve how the People Operations function works, from automating repeatable tasks to surfacing better insights• Own end-to-end operational execution across the employee lifecycle: hiring operations, onboarding, offboarding, transfers, and leaves• Ensure all people data, headcount, organizational structure, compensation, employment status, is accurate, complete, and audit-ready• Manage the operational components of performance cycles, engagement surveys, and other recurring people programs• Build scalable processes and playbooks that can flex as the company grows• Manage end to end benefits administration, including open enrollment, and carrier relationships in partnership with brokers• Identify and recommend improvements to the benefits portfolio based on employee data, market trends, and cost analysis• Own compensation...