Scientist II, Bioinformatics QC

Jobs at Aspen Neuroscience Scientist II, Bioinformatics QC San Diego, California Type: Full-time Min. Experience: Senior Level Salary: $129,600 - $158,400 Aspen Neuroscience is seeking a Scientist II, Bioinformatics QC to join our team. In this role you will be taking ownership of a critical priority, bringing together multiple teams and ensuring the quality of our product, contributing directly to delivering novel cell therapy to patients. You will be responsible for applying bioinformatics and genomics expertise supporting Quality Control operations for clinical-stage cell therapy manufacturing. In being responsible for executing and analyzing multi-omics QC workflows, as well as improving our bioinformatics processes, you will directly impact & influence the lives of patients with Parkinsons Disease. This is an on-site role in Torrey Pines, CA that requires flexibility and availability for weekend and holiday work as needed. Relocation is not available. DUTIES AND RESPONSIBILITIES: Execute bioinformatics QC analyses across multi-omics assays (e.g., RNA-seq, WGS, structural variation, epigenetic profiling) to support product quality assessment and release Analyze and interpret data against established acceptance criteria; escalate atypical results and support investigation activities Prepare and maintain compliant documentation supporting QC review, deviation investigations, and audit readiness Support root cause analysis and re-analysis workflows for QC deviations and process excursions Maintain traceability of data, methods, and outputs in alignment with GMP and data integrity expectations Collaborate with QC, QA, Manufacturing, and R&D teams to support sample processing timelines and data delivery Contribute to process improvements, workflow optimization, and automation initiatives for bioinformatics QC Assist in development and evaluation of new analytical methods to support characterization of product lots and intermediates Support qualification and validation activities for bioinformatics pipelines and systems EDUCATION AND EXPERIENCE: PhD in Bioinformatics, Genomics, Computational Biology, or related field (or equivalent combination of education and relevant experience) Hands-on experience with NGS data analysis pipelines (RNA-seq, WGS, or similar) Experience working in drug development or other regulated environments (GMP/GxP), including understanding of data integrity expectations   JOB SPECIFICATIONS: Genomics Expertise: Strong understanding of human genetics and genomics, including variant analysis, gene expression, and structural variation in applied settings Programming: Proficiency in scripting and data analysis tools (e.g., Python, R, Bash) to support reproducible workflows Data Quality: Excellent attention to detail with demonstrated ability to produce accurate, high-quality, and traceable datasets QC/QA Processes: Familiarity with QC and QA workflows, documentation practices, and audit readiness requirements Biological Interpretation: Ability to interpret biological and genomics data in clinical or translational contexts to support QC decision-making Communication: Strong written and verbal communication skills, with the ability to clearly document and explain analytical methods and results Scientific Judgment: Comfort working with ambiguity and applying scientific reasoning to analyze and troubleshoot real-world datasets Validation & Systems: Exposure to qualification and validation of bioinformatics systems and pipelines in regulated environments Workflow Design: Ability to contribute to the design, improvement, and scaling of bioinformatics workflows and organizational systems   WORKING CONDITIONS Office and Lab environment. While performing the duties of this Job, the employee is frequently exposed to toxic or caustic chemicals. This is an indoor position requiring the ability to perform experiments in the laboratory, and type and use a...