Senior Bioinformatics Engineer

Sequencing is building the interface between humanity and its DNA.
Using clinical-grade whole genome sequencing, AI, and a rapidly expanding ecosystem of genomic applications, we help people better understand themselves, their health, and their future through their DNA.
The human genome is one of the most valuable and underutilized resources in the world. Our mission is to transform the human genome into a lifelong source of personalized guidance and build the trusted home for every genome on Earth.
As the world’s largest direct-to-consumer whole genome sequencing platform, Sequencing is helping define the future of AI-powered personalized health.
We’re a profitable, venture-backed, fully remote company building category-defining products that help people better understand themselves through their DNA.

The Position
Sequencing.com is hiring a Senior Bioinformatics Engineer to develop cutting edge genomic analysis tools and infrastructure for the Bioinformatics team. You build the data analysis and interpretation that helps users uncover meaningful insights about their health, wellness, and ancestry from their DNA. This role requires expertise in cloud technologies, large scale genomic data processing, and software development. Your work helps power the future of personal genomics.
The Impact

• Design, build, and maintain scalable pipelines for processing and analyzing clinical grade 30x whole genome data.
• Support a wide range of genomic data types at consumer scale.
• Optimize performance, reliability, and cost of data processing pipelines across AWS and hybrid environments.
• Keep throughput high and latency predictable for end users.
• Develop production quality services and tools using Python, C#, SQL, and AWS, including Lambda, Glue, Batch, S3, and RDS.
• Power Sequencing's DNA apps and reports with the services and tools you build.
• Collaborate across product, science, engineering, and UX teams to translate scientific findings into clear, consumer friendly genetic insights that are easy to navigate.
• Establish and adhere to best practices for software engineering, data versioning, testing, observability, and documentation across bioinformatics workflows.
• Debug complex data and infrastructure issues with a systematic approach.
• Operate and improve production systems where correctness and reliability are critical.
• Leverage AI tools to increase productivity, code quality, and testing depth.
• Deliver high quality, validated output.

Dominant and Expressed Traits

• 5+ years of experience in bioinformatics, computational biology, computer science, or a related field.
• Strong hands on experience working with real world genomic datasets and file formats such as VCF, BAM, and FASTQ.
• Solid understanding of genomic databases, standards, and annotation resources.
• Proficient in Python, SQL, and C#, with a track record of writing clean, maintainable code.
• Designed and implemented bioinformatics pipelines and data processing systems in production.
• Built scalable, reliable systems on cloud platforms such as AWS, including the use of managed services.
• Familiar with containerization and orchestration technologies such as Docker and Kubernetes.
• Excellent problem solving skills and exceptional attention to detail.
• Fluent in English, both written and verbal, with clear communication across technical and non technical stakeholders.

Benefits Overview

• Comprehensive medical, dental, and vision insurance coverage
• 401(k) with company matching
• Paid time off (PTO)
• Paid volunteer time off
• Fully remote work with home office stipend
• Parental bonding leave
• Clinical-grade whole genome sequencing for you and your family (private and confidential)

Join Sequencing

• Redefine how people understand themselves through their DNA
• Build category-defining products alongside scientists, engineers, and innovators
• Contribute to technology that will improve and extend millions of lives
• Shape one of the most important emerging categories in AI and healthcare

Sequencing Inc. is an equal opportunity employer. All aspects of employment, including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law. Where required by applicable law, candidates may request a reasonable accommodation or an alternative selection process by contacting joinus@sequencing.com.
Sequencing Inc. may use artificial intelligence (AI) or automated tools as part of the recruiting and hiring process, including for application screening and candidate evaluation. These tools may analyze information provided in your application materials or during the hiring process.
All legitimate Sequencing roles are posted on our official careers page and require you to apply through our company application portal. If a role claiming to be with Sequencing asks you to apply or communicate outside of those channels, it is not an authentic opportunity with our team. During our hiring process, we or our recruitment partners will never ask you to send money, purchase equipment, or share bank, credit card, or Social Security information before a verified offer. We also will not make same day offers without interviews or ask you to communicate only through informal messaging apps. If you believe someone is misusing our name in a fake posting, please report it to the job board or verify the posting by contacting careers@sequencing.com.

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