Sr. Medical Director

All Jobs  >  Sr. Medical Director Apply Sr. Medical Director Lexington, MA Apply Job Type Full-time Description   About TRIANA Biomedicines TRIANA Biomedicines is a Greater Boston biotechnology company building the leading molecular glue discovery platform to regulate disease targets that are difficult to address with any other modality. TRIANA’s drug discovery engine is powered by high-resolution structural insights, state-of-the-art AI and computational tools, and bespoke chemical libraries. TRIANA’s target-first and rational approach to molecular glue discovery is currently focused on inducing or enhancing the degradation of high-profile cancer targets. The therapeutic approach pioneered by TRIANA has the potential to fundamentally change the paradigm of small molecule drug discovery and bring significant therapeutic benefits to patients.  TRIANA is a private company with a top-tier investor syndicate. Position Overview:We are seeking a Senior/Executive Medical Director to lead early-phase oncology clinical development. This role serves as the primary medical lead for one or more investigational compounds from first-in-human through proof of concept, driving clinical strategy, ensuring patient safety, and advancing programs toward key milestones.You will work cross-functionally with translational science, biomarkers, regulatory, and portfolio teams to define and execute development plans. The ideal candidate is a physician-scientist with deep oncology expertise, hands-on early-phase trial experience (including CRO oversight), and a strong commitment to delivering innovative therapies to patients. Regulatory and global experience are a plus.Key Responsibilities:Clinical StrategyServe as the Medical Lead for early-phase oncology      programs (FIH through proof of concept). Develop Clinical Development Plans, including      indication strategy, study design, and decision criteria. Define dose-escalation approaches, expansion cohorts,      and patient selection in partnership with translational and biomarker      teams. Drive data-informed decisions through safety reviews,      data analyses, and portfolio discussions. Study Design & ExecutionAuthor and oversee key clinical documents (protocols,      IBs, ICFs, CSRs). Provide medical oversight for trial execution,      including safety monitoring and investigator engagement. Lead medical monitoring activities (AE review, signal      detection, dose management). Participate in or chair SRCs, DMCs/IDMCs, and      internal governance meetings. Partner with biostatistics on endpoints and analysis      plans aligned with regulatory expectations. Regulatory & Scientific EngagementContribute to regulatory submissions (INDs,      amendments, briefing documents, responses). Support regulatory interactions as a medical expert      (FDA, EMA, global agencies). Build relationships with KOLs, academic institutions,      and patient advocacy groups. Lead publications and present data internally, at      conferences, and to external stakeholders. Cross-Functional LeadershipServe as a core Program Team member, providing      medical leadership across functions. Mentor junior clinical staff and contribute to team      development. Support business development activities, including      scientific due diligence and partnerships. Qualifications:RequiredMD, MD/PhD, or DO with board      certification/eligibility in Oncology, Hematology/Oncology, or related      field. 10+ years of industry experience, including 5+ years      in biotech drug development. Proven leadership in Phase I/II oncology trials,      including FIH studies. Strong expertise in oncology biology, biomarkers, and      precision medicine. Experience with regulatory submissions and health      authority interactions. Excellent communication skills with the ability to      translate complex data clearly. PreferredExperience with accelerated regulatory...